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During alcohol abuse, the demand for ketone bodies in the brain increases, and adaptation to repeated alcohol intake occurs, while acetate levels decline during withdrawal, and supplementation of ketone bodies through a KD may alleviate withdrawal symptoms due to the sudden shift in metabolic status (106)

The process of thyroid hormone production When the pituitary produces TSH, this sends the signal to the thyroid gland to produce mostly thyroxine T4 which is the inactive form

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Meanwhile, phenothiazine-based derivatives compound 51 , although it has shown neuroprotective effects in IS animal models, still has high hERG inhibitory activity (Yang et al., 2021